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生半夏姜制或煎煮对小鼠妊娠及胚胎发育的影响

徐建亚 谢辉辉 单进军 徐珊 汪受传

徐建亚, 谢辉辉, 单进军, 徐珊, 汪受传. 生半夏姜制或煎煮对小鼠妊娠及胚胎发育的影响[J]. 南京中医药大学学报, 2013, 29(3): 255-258.
引用本文: 徐建亚, 谢辉辉, 单进军, 徐珊, 汪受传. 生半夏姜制或煎煮对小鼠妊娠及胚胎发育的影响[J]. 南京中医药大学学报, 2013, 29(3): 255-258.
XU Jian-ya, XIE Hui-hui, SHAN Jin-jun, XU Shan, WANG Shou-chuan. Different Effects of Rhizoma Pinelliae Processed by Ginger or Decocting on Gestation and Embryonic Development of Mice[J]. Journal of Nanjing University of traditional Chinese Medicine, 2013, 29(3): 255-258.
Citation: XU Jian-ya, XIE Hui-hui, SHAN Jin-jun, XU Shan, WANG Shou-chuan. Different Effects of Rhizoma Pinelliae Processed by Ginger or Decocting on Gestation and Embryonic Development of Mice[J]. Journal of Nanjing University of traditional Chinese Medicine, 2013, 29(3): 255-258.

生半夏姜制或煎煮对小鼠妊娠及胚胎发育的影响

Different Effects of Rhizoma Pinelliae Processed by Ginger or Decocting on Gestation and Embryonic Development of Mice

  • 摘要: 目的 研究生半夏姜制或煎煮对小鼠妊娠及胚胎发育的影响,初步探讨半夏减毒的影响因素。方法 采用一般急性毒性实验法及致畸敏感期药物生殖毒性实验方法,分别比较了生半夏粉混悬液、姜半夏粉混悬液,生半夏汤剂对小鼠的急性毒性及对小鼠妊娠与胚胎发育的影响。结果 急毒试验中,生半夏混悬液(36 g/kg)与生半夏汤剂(180 g/kg)给药后,小鼠死亡率分别为50%、22.2%;姜半夏混悬液组(36 g/kg)与正常组无显著差异。生殖毒性试验中,生半夏混悬液6 g/kg剂量母鼠死亡率达30%,孕期增重少,胎仔尾长短,与正常对照组差异显著(P<0.05);生半夏汤剂30 g/kg对母鼠无影响,胎仔身长短于正常对照组(P<0.05);姜半夏混悬液6 g/kg给药后,所有指标与正常对照组无显著差异。结论 生半夏混悬液急性毒性较高且有显著的母体毒性及胚胎毒性;煎煮后其汤剂毒性降低,对母体无毒性但影响胎仔的生长发育;姜半夏混悬液无任何母体或胚胎毒性。

     

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出版历程
  • 收稿日期:  2013-03-04
  • 修回日期:  2013-04-20
  • 刊出日期:  2013-05-10

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