左五合方对卵巢低反应者IVF/ICSI-ET助孕结局的影响
Effect of Zuowu Decoction on the Outcome of Poor Ovarian Response Patients with IVF/ICSI-ET
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摘要: 目的 评价左五合方对卵巢低反应(POR)者体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)卵巢反应性、妊娠相关指标的影响。方法 将100例肾精不足合脾气虚型POR患者随机分为治疗组和对照组各50例,2组均常规行IVF/ICSI-ET,其中治疗组以左五合方治疗3月再行IVF/ICSI-ET。比较2组患者促性腺激素(Gn)用量及用药天数、人绒毛膜促性腺激素(HCG)注射日雌二醇(E2)及孕酮(P)水平、获卵数、优胚率、生化妊娠率、临床妊娠率、持续妊娠率。结果 2组Gn用量及用药天数、HCG日E2和P水平、优胚率、生化妊娠率差异均无统计学意义(P>0.05);治疗组获卵数、临床妊娠率、持续妊娠率均高于对照组(P<0.05)。结论 左五合方能提高POR者IVF/ICSI-ET的获卵数、临床妊娠率和持续妊娠率。
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关键词:
- 左五合方 /
- 卵巢低反应 /
- 体外受精/卵胞质内单精子注射-胚胎移植
Abstract: OBJECTIVE To evaluate the impact of Zuowu decoction on ovarian response and pregnancy related indicators of poor ovarian response (POR) patients with in vitro fertilization/ intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). METHODS 100 patients with POR due to deficiency of kidney-essence and spleen-qi were randomly divided into the treatment group and the control group with 50 cases in each. Both groups received routine IVF/ICSI-ET while the treatment group was pre-administrated with Zuowu Decoction for 3 months, and then given IVF/ICSI-ET. The dosage and administration duration of gonadotropin (Gn), the levels of estradiol (E2) and progesterone (P) on human chorionic gonadotropin(HCG) trigger day, number of retrieved oocytes, high-quality embryo rates, biochemical pregnancy rate, clinical pregnancy rate and ongoing pregnancy rate were compared between the two groups. RESULTS The differences of the following indicators were no statistically significant: the dosage and administration duration of Gn, the level of E2 and P on HCG trigger day, high-quality embryo rates and biochemical pregnancy rate (P>0.05). The number of retrieved oocytes, clinical pregnancy rate and ongoing pregnancy rate in the treatment group were all higher than those in the control group (P<0.05). CONCLUSION Zuowu Decoction can increase the number of retrieved oocytes, clinical pregnancy rate and ongoing pregnancy rate in POR patients with IVF/ICSI-ET treatment.-
Key words:
- Zuowu Decoction /
- poor ovarian response /
- IVF/ICSI-ET
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