潜阳育阴颗粒治疗阴虚阳亢型高血压早期肾损害患者的临床研究

刘健; 李碧霞; 杜金玲; 蒋卫民

潜阳育阴颗粒治疗阴虚阳亢型高血压早期肾损害患者的临床研究

1.
南京中医药大学附属医院，江苏南京 210029
2.
南京中医药大学第一临床医学院，江苏南京 210023
3.
松原市中心医院心内科，吉林松原 138001

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出版历程
- 刊出日期: 2019-05-10

Clinical Study of Qianyang Yuyin Granules Treating Early Renal Damage Patients with Yin Deficiency and Yang Hyperactivity Type Hypertension

1.
Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China
2.
The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, China
3.
Department of Cardiology, Songyuan Central Hospital, Songyuan, 138001, China

摘要

摘要: 目的观察潜阳育阴颗粒对阴虚阳亢型高血压早期肾损害患者的临床疗效。方法将60例阴虚阳亢型老年高血压早期肾损害病例，随机分为对照组（30例）和观察组（30例），对照组常规使用西药氨氯地平（或者联合缬沙坦）降压，观察组在对照组降压治疗维持达标的基础上服用中药潜阳育阴颗粒。24周后比较2组患者治疗前后的临床疗效、单光子发射计算机化体层显像术（SPECT）检测肾小球滤过率（GFR）和胱抑素C（Cyst-C）、尿β₂微球蛋白（β₂-MG）以及尿N-乙酰-β-D葡萄糖苷酶（NAG）等早期肾损害指标的变化情况。结果治疗后观察组和对照组的有效率分别为96%和50%，2组比较有显著性差异，P＜0.01;2组肾损害指标Cyst-C、β₂-MG水平均有显著改善（P<0.05），观察组较对照组改善效果更为显著（P<0.05）;观察组肾损害指标(GFR、NAG)有显著改善（P<0.05）;观察组优于对照组（P<0.05）。结论潜阳育阴颗粒在降压达标基础上能够有效减少高血压患者的早期肾脏损害，改善临床症状。
- 高血压早期肾损害 /
- 单光子发射计算机化体层显像术 /
- 潜阳育阴颗粒
Abstract: OBJECTIVE To observe the clinical effect of Qianyang Yuyin granules treating early renal damage patients with yin deficiency and yang hyperactivity type hypertension. METHODS 60 elderly early renal damage patients with yin deficiency and yang hyperactivity type hypertension were randomly divided into two groups: the control group (30 cases) and the observation group (30 cases). In the control group， western medicine amlodipine (or combined with valsartan) was given to reduce blood pressure. The observation group wasn't given Qianyang Yuyin granules until the reduced hypertension adhered to the standard on the basis of those medications used in the control group. 24 weeks later， in addition to comparing the clinical efficacy of the two groups， the research also compared the changes of the early renal damage indexes: glomerular filtration rate (GFR) detected by single photon emission computed tomography (SPECT)， cystatin C (Cyst-C)， urinary β₂ microglobulin (β₂-MG)， urine N-acetyl-β-D glycosidase (NAG) and so forth. RESULTS After treatment， the effective rates of the observation group and the control group were 96% and 50% successively， of which differences were significant (P<0.01). The levels of the early renal damage indexes， Cyst-C and β₂-MG， in the two groups were significantly improved (P<0.05)， and the improvement effect in the observation group was more significant than that in the control group (P<0.05). The renal damage indexes (GFR， NAG) in the observation group were significantly improved (P<0.05)， and were superior to that in the control group (P< 0.05). CONCLUSION Qianyang Yuyin granules can effectively reduce the early renal damage for hypertension patients on the basis of the reduced hypertension adhering to the standard and improve the clinical symptoms.
- early renal damage due to hypertension /
- single photon emission computed tomography /
- Qianyang Yuyin granules

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