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活血通腑方对术后腹腔粘连大鼠肠黏膜免疫屏障功能的影响

颜帅 乐音子 杨丽丽 卞尧尧 曾莉

颜帅, 乐音子, 杨丽丽, 卞尧尧, 曾莉. 活血通腑方对术后腹腔粘连大鼠肠黏膜免疫屏障功能的影响[J]. 南京中医药大学学报, 2017, 33(5): 519-523.
引用本文: 颜帅, 乐音子, 杨丽丽, 卞尧尧, 曾莉. 活血通腑方对术后腹腔粘连大鼠肠黏膜免疫屏障功能的影响[J]. 南京中医药大学学报, 2017, 33(5): 519-523.
YANShuai, YUEYin-zi, YANGLi-li, BIANYao-yao, ZENGLi. Effects of Classical Prescriptions of Blood-activating and Organ-purging Formula on Immunologic Barrier Function of Intestinal Mucosa in Rats with Postoperative Peritoneal Adhesion[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(5): 519-523.
Citation: YANShuai, YUEYin-zi, YANGLi-li, BIANYao-yao, ZENGLi. Effects of Classical Prescriptions of Blood-activating and Organ-purging Formula on Immunologic Barrier Function of Intestinal Mucosa in Rats with Postoperative Peritoneal Adhesion[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(5): 519-523.

活血通腑方对术后腹腔粘连大鼠肠黏膜免疫屏障功能的影响

Effects of Classical Prescriptions of Blood-activating and Organ-purging Formula on Immunologic Barrier Function of Intestinal Mucosa in Rats with Postoperative Peritoneal Adhesion

  • 摘要: 目的 观察活血通腑方对术后腹腔粘连早期肠道黏膜屏障的影响。方法 取SD雄性大鼠60只,随机分为对照组、模型组、活血通腑方组,除对照组外,其余动物均采用锉刀法构建腹腔粘连大鼠模型,分别于术后第3、6、12 h和24 h给予相应剂量的药物,术后48 h采血及组织样本,ELISA法测定血浆中TNF-α水平,免疫组化法检测肠黏膜sIgA的含量和CD4细胞数量,TUNEL法检测肠黏膜下淋巴细胞凋亡情况。结果 与对照组相比,6、12 h和24 h后模型组血浆中TNF-α水平具有统计学差异(P<0.05~0.01);3、6 h模型组黏膜sIgA表达明显下降;肠黏膜下淋巴细胞凋亡明显(P<0.01),12、24 h时sIgA的分泌量明显增多(P<0.05);而模型组12、24 h与3、6 h相比,黏膜下淋巴细胞凋亡明显下降接近对照组水平;模型组3 h肠道黏膜CD4细胞数量明显下降(P<0.01);6、12、24 h时CD4细胞数量3组比较未见明显异常(P>0.05)。活血通腑方在术后3 h可显著降低模型鼠血浆中TNF-α水平;增高肠道黏膜sIgA含量和CD4细胞数量;减弱黏膜下淋巴细胞凋亡。结论 活血通腑方组可通过降低血TNF-α的水平,减轻黏膜下淋巴细胞凋亡,增加肠道黏膜sIgA含量和CD4细胞数量,提高局部免疫水平,抑制炎症反应。

     

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    [6] 曾莉,钱海华,赵群男,等.活血通腑方治疗术后粘连性肠梗阻56例临床观察[J].南京中医药大学学报,2010,26(3):346-348.
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出版历程
  • 收稿日期:  2016-10-18
  • 修回日期:  2017-03-22
  • 刊出日期:  2017-09-10

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