代谢组学在儿科疾病中的应用
Metabolomics Applied to Pediatric Diseases: Opportunities and Challenges
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摘要: 儿童期是人类个体生命周期中的起始阶段,儿科疾病有其特有的生理病理机制及诊疗方法。代谢组学通过监测生物体内源性代谢产物的变化来反应机体的生理或病理状态,并发现疾病相关的生物标记物。近年来,代谢组学技术逐渐被应用于儿科疾病,为疾病的预防、诊断和治疗带来新的契机。文章从“治未病”和“治已病”两个角度出发,综述了代谢组学技术在研究儿科疾病生理病理机制中的应用,并提出其应用于儿科疾病证候学研究的设想。Abstract: Childhood is a specific life period. Pediatric disease has its unique physiological and pathological mechanism and thereby it requires distinctive considerations and special treatments. Metabolomics is used to monitor the body's physiological or pathological state by monitoring the changes of endogenous metabolites and biomarkers related to diseases, which provides a new basis for diagnosis and treatment of disease. In recent years, metabolomics has gradually been applied to pediatric diseases, bringing new opportunities for prevention, diagnosis and treatment of the diseases. This paper reviews the application of metabolomics to pathophysiological study of pediatric diseases from the two aspect of "preventive treatment of disease" and "treatment of diseases", and further put forward the conceive of its application to TCM syndrome research of pediatric diseases.
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Key words:
- metabolomics /
- pediatrics /
- physiology /
- pathology /
- TCM syndrome
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