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参芪扶正注射液对消化道肿瘤化疗的辅助作用研究

张公正 陈红涛

张公正, 陈红涛. 参芪扶正注射液对消化道肿瘤化疗的辅助作用研究[J]. 南京中医药大学学报, 2017, 33(2): 140-143.
引用本文: 张公正, 陈红涛. 参芪扶正注射液对消化道肿瘤化疗的辅助作用研究[J]. 南京中医药大学学报, 2017, 33(2): 140-143.
ZHANGGong-zheng, CHENHong-tao. Supplementary Role of Shenqi Fuzheng Injection to Digestive Tract Tumor During Chemotherapy[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(2): 140-143.
Citation: ZHANGGong-zheng, CHENHong-tao. Supplementary Role of Shenqi Fuzheng Injection to Digestive Tract Tumor During Chemotherapy[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(2): 140-143.

参芪扶正注射液对消化道肿瘤化疗的辅助作用研究

Supplementary Role of Shenqi Fuzheng Injection to Digestive Tract Tumor During Chemotherapy

  • 摘要: 目的 探讨参芪扶正注射液在消化道肿瘤化疗过程中的临床辅助作用及对化疗引起的不良反应的改善效果。方法 收集2014-2016年本院收治的消化道肿瘤患者156例,随机平均分为联合化疗组(78)和对照组(78)。对2组病人进行常规化疗方案,联合化疗组加用参芪扶正注射液250 mL/d静脉滴注。化疗结束后对化疗疗效进行评价,计算化疗有效率和疾病控制率(DCR)。分别于化疗前后检测CD3+、CD4+、CD8+、CD4+/CD8+及NK细胞的活性和外周血细胞水平;记录和统计化疗过程中的不良反应出现情况。结果 化疗后联合化疗组疗效分布与对照组差异有统计学意义(P<0.05)。化疗后2组血细胞水平均下降,对照组免疫细胞活性下降,而联合化疗组升高,组间比较联合化疗组CD3+、CD4+、CD4+/CD8+、NK及各血细胞水平均高于对照组(P<0.05);化疗过程中联合化疗组不良反应出现率为74.35%,低于对照组88.46%(P<0.05)。结论 注射参芪扶正注射液可以在一定程度上提高消化道肿瘤患者的化疗效果,并可以改善化疗后的免疫低下和化疗不良反应状况。

     

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出版历程
  • 收稿日期:  2016-10-14
  • 修回日期:  2017-01-12
  • 刊出日期:  2017-03-10

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