Abstract: OBJECTIVE To explore the clinical efficacy of using Chaizhi Pinggan decoction to treat functional dyspepsia of liver-stomach disharmony type and its mechanism. METHODS 110 patients with functional dyspepsia due to liver-stomach disharmony were selected from March， 2015 to March， 2016 in our hospital and randomly divided into the observation group and the control group， with 55 cases in each group. The control group was given domperidone tablets while the observation group were given Chaizhi Pinggan Decoction. After 4 weeks treatment， changes in clinical symptoms and signs， serum serotonin(5HT) and somatostatin(SS) content in the two groups were detected and compared. The recurrence incidence of the two groups during the three-month follow up were observed. RESULTS Such symptoms as abdominal fullness and distention， hypochondriac pain， prone to sign， poor appetite， nausea， belching and vomiting all decreased significantly(P<0.05~0.01)， but the observation group reduced more significantly compared with the control group(P<0.05~0.01). TCM syndrome total scores of both groups decreased significantly after treatment(P<0.01)， but the observation group reduced more significantly(P<0.01). The total efficiency of epigastric pain syndrome and postprandial distress syndrome in the observation group were 92.8% and 92.6%， which were much higher than those in the control group72.4% and 69.2%(P<0.05). After treatment both serum 5HT and SS in the two groups went down significantly(P<0.01)， with more decrease in the observation group(P<0.05). During the three-month follow ups， the recurrence rate of the observation group was 3.6%， lower than 12.7% of the control group(P<0.05). CONCLUSION Chaizhi Pinggan Decoction can significantly improve clinical symptoms of patients with functional dyspepsia due to liver and stomach disharmony， whose mechanism might be related to the increase of 5HT and decrease of SS.