黄芪桂枝五物汤治疗奥沙利铂化疗后周围神经毒性24例

李道明; 王蓉; 谢菁

黄芪桂枝五物汤治疗奥沙利铂化疗后周围神经毒性24例

苏州大学附属第一医院，江苏苏州 215006

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出版历程
- 收稿日期: 2013-12-21
- 修回日期: 2014-01-20
- 刊出日期: 2014-03-10

Clinical Study on Huangqi Guizhi Wuwu Decoction Treating the Neuro-sensory Toxicity Caused by Oxaliplatin

摘要

摘要: 目的观察黄芪桂枝五物汤减轻对奥沙利铂神经毒性的疗效。方法对接受FOLFOX6方案化疗的48例大肠癌患者，随机分为对照组和治疗组。对照组单接受化疗，治疗组在接受奥沙利铂化疗的同时配合服用黄芪桂枝五物汤中药治疗。奥沙利铂引起的周围神经毒性评定参考Levi专用标准。结果治疗组24例，发生周围神经毒性1级8例，2级1例，3级0例，4级0例，总发生率为37.5%。对照组24例中发生周围神经毒性1级13例，2级3例，3级3例，4级0例，总发生率为79.17%。2组比较，治疗组在接受奥沙利铂治疗时神经毒性的发生率及3～4级毒性反应发生程度明显减低，差异有统计学意义（P<0.01）。结论黄芪桂枝五物汤能有效防治奥沙利铂的周围神经毒性。
- 黄芪桂枝五物汤 /
- 奥沙利铂 /
- 周围神经毒性
Abstract: OBJECTIVE To observe the curative effect of Huangqi Guizhi Wuwu Decoction in the treatment of neuro-sensory toxicity caused by oxaliplatin. METHODS 48 cases of colorectal cancer were randomly divided into the control group (24 cases) treated with chemotherapy alone and the treatment group (24 cases) treated with Huangqi Guizhi Wuwu Decoction additionally. The neuro-sensory toxicity caused by oxaliplatin was judged by Levi standard. RESULTS Among 24 cases in treatment group， 8 cases presentedⅠclass， 1 patientⅡclass， and 0 patients Ⅲ / Ⅳclass， the total occurrence being 79.17%. In the control group， 13 cases presentedⅠclass， 3 patientⅡclass， 3 patients Ⅲ class and 0 case Ⅳclass. Compared with control group， there were less patients got Ⅲ/Ⅳ class toxic reaction in treatment group， which suggested a significant difference (P<0.01). CONCLUSION Huangqi Guizhi Wuwu Decoction has a significant effect on the neuro-sensory toxicity caused by oxaliplatin.
- Huangqi Guizhi Wuwu Decoction /
- oxaliplatin /
- neuro-sensory toxicity

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