大鼠在体单向肠灌流模型研究毛蕊异黄酮的吸收特征

Study on Absorption Characteristics of Calycosin in Single-pass Intestinal Perfusion Models in Vivo

1.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
2.
Engineering Center of Jiangsu Province for Efficient Administration System of Chinese Medicine, Nanjing, 210023, China

摘要: 目的研究毛蕊异黄酮肠吸收动力学特征。方法采用大鼠在体单向肠灌流模型，以酚红为标示物，研究毛蕊异黄酮在大鼠不同肠段的吸收特征。结果毛蕊异黄酮在不同肠段均有吸收，且在结肠段吸收最好，不同浓度药物在结肠吸收中存在自身浓度抑制作用。结论毛蕊异黄酮在小肠中吸收较好，其吸收机制可能是主动转运。
- 毛蕊异黄酮 /
- 单向肠灌流 /
- 肠吸特征
Abstract: OBJECTIVE To study the dynamic characteristics of intestinal absorption of calycosin using signal-pass perfusion model in rats. METHODS After one-way intestinal perfusion model of rat in situ was set up，by taking phenolsulfonphthalein a maker，the absorption characteristics of different intestinal segments. RESULTS Calycosin have a good stability separately in different intestinal segments and in the colon to absorb the best. Different concentrations of drug in the colon absorption in inhibition of its concentration. CONCLUSION Calycosin is well absorbed in the small intestine and calycosin absorption may active transport.
- calycosin /
- rat single-pass intestinal perfusion /
- intestine absorption kinetics

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