饮食发物对小鼠变应性接触性皮炎模型的影响
Effects of Stimulating Food on Allergic Contact Dermatitis in BALB/c mice
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摘要: 目的 观察饮食发物对小鼠变应性接触性皮炎（ACD）模型的影响，探讨可能的作用机制。方法 诱导建立小鼠ACD模型，观察羊肉、竹笋、黄酒、辣椒、海虾在诱发后48 h对小鼠模型炎症反应及相关细胞因子的影响。结果 与对照组比较羊肉、黄酒、青椒组能明显增加小鼠耳肿胀及炎症细胞浸润数量（P<0.05），竹笋、海虾组无统计学差异（P>0.05）；耳质量差除羊肉组外，各组与对照组之间差异无统计学意义（P>0.05）；羊肉、黄酒、青椒组升高外周血IFN-γ、IL-17、IL-2表达水平（P<0.05），竹笋组降低（P<0.05），海虾组无明显影响（P>0.05）。结论 羊肉、青椒、黄酒有加重小鼠ACD作用，其机制可能与上调细胞因子表达水平有关。竹笋、海虾对小鼠ACD无影响。Abstract: OBJECTIVE To study the effects of diet fawu on allergic contact dermatitis (ACD) in mice models and to explore the possible mechanism. METHODS Mice models of ACD was established and the effects of mutton， bamboo shoots， yellow wine， green pepper， sea shrimp on inflammatory reaction and related cytokines was observed respectively at 48 h after elicitation. RESULTS Compared with the control group， mutton， yellow wine， green pepper groups can significantly increase the ear swelling and the number of infiltrating inflammator cells in mice models（P<0.05）， bamboo shoots， sea shrimp groups showed no significant difference (P>0.05). The ear weight changes of each group except mutton showed no significant difference compared with the control group (P>0.05); mutton， yellow wine， green pepper groups can markedly increase expression level of IFN- γ， IL-17， IL-2 in peripheral blood (P<0.05)， bamboo shoots group decreased (P<0.05)， no significant effect of shrimp group (P>0.05). CONCLUSION Mutton， green peppers， yellow wine can aggravate ACD in mice possibly by up-regulation the expressions of IFN-γ， IL-17， IL-2. Bamboo shoots and sea shrimp have no effect on mice ACD.
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Key words:
- diet fawu /
- allergic contact dermatitis /
- inflammation /
- cytokine
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