丹参滴注液中的过敏物质研究
The Allergic Substances in Danshen Drip
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摘要: 目的 追踪丹参滴注液中的过敏性成分。方法 以5-羟色胺为指标，卵蛋白为阳性药物，对致敏时间、攻击时间进行优化从而获得最优的动物模型，通过上述模型筛选出丹参滴注液中的过敏性成分。结果 每只豚鼠每次隔日皮下注射供试品溶液0.2 mL进行致敏，共3次，于首次注射给药后第16天，腹腔再次注射供试品溶液0.5 mL进行攻击。结论 确定丹参滴注液中致敏性成分为丹参蛋白。Abstract: OBJECTIVE To track the allergic substances in Danshen Drip. METHODS 5-hydroxy tryptamine and ovalbumin were taken as index and positive drug respectively to optimize the sensitization time and attacking time in order to obtain the optimized animal model through which the allergic substances in Danshen Drip was selected. RESULTS Each guinea pig was subcutaneously injectioned with 0.2 mL Danshen Drip on alternate days for three times， 16 days after the first injection， each guinea pig was undertaken subcutaneous injection with 0.5 mL for repeated attack.CONCLUSION The allergic substance of Danshen Drip is salvia miltiorrhiza protein.
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[1] 张胜东，张荣太．丹参注射液临床应用分析与风险控制[J]．中国医院用药评价与分析，2011， 11（1）：70-73． [2] Zhang SD， Zhang RT.Clinical application and risk control of Danshen Drip[J]. Eval Anal Drug-use Hosp Chin， 2011， 11(1): 70-73. [3] 国家药典委员会．中华人民共和国药典:一部[S]. 北京：中国医药科技出版社，2010:附录92． [4] Chinese Pharmacopeia Committee.Pharmacopoeia of The People's Republic of China [S]. Beijing: Chinese medical science and technology press，2010:appendix 92. [5] 李洪亮，熊辉，陈永刚，等．高效液相色谱法测定人血清中5-羟色胺含量[J]．山西医药杂志，2009， 38（10）：876-877． [6] Li HL， Xiong H， Chen YG， et al.Determination of 5-hydroxy tryptamine content in serum by HPLC[J]. Shanxi Med J， 2009， 38(10): 876-877. -
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