犀角地黄汤对瘀热证H型高血压大鼠TNF-α、IL-6及血液流变学的影响

刘红权; 黄厚才; 钟荣玲; 夏智; 郭立中; 王省

犀角地黄汤对瘀热证H型高血压大鼠TNF-α、IL-6及血液流变学的影响

1.
南京中医药大学第一临床医学院，江苏南京 210023
2.
南京中医药大学附属江苏省中西医结合医院，江苏南京 210028

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出版历程
- 收稿日期: 2013-06-11
- 修回日期: 2013-08-01
- 刊出日期: 2013-09-10

Effects of Xijiao Dihuang Decoction on the TNF-α， IL-6 and Hemorheology of Stagnated-heat Syndromes and H-hypertensive rats

1.
The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, 210023, China
2.
Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, 210028, China

摘要

摘要: 目的探讨犀角地黄汤对瘀热证H型高血压（血同型半胱氨酸水平-Hcy升高同时伴有高血压）大鼠肿瘤坏死因子-a（TNF-α）、白细胞介素-6（IL-6）及血液流变学的影响。方法造模瘀热证H型高血压大鼠成功后采用低中高3种不同剂量犀角地黄汤（含生药量0.75、1.5、3.0 g/mL）水煎液灌服，并选择空白对照，分别检测各组血TNF-α、IL-6及血液流变学，并对检测结果进行统计分析。结果治疗前后比较，犀角地黄汤治疗组对瘀热证H型高血压组的TNF-α、IL-6及血液流变学的影响与对照组相比有明显差异，差异有统计学意义（P<0.01），尤其以中低剂量为佳。结论犀角地黄汤能够有效干预瘀热证H型高血压大鼠的TNF-α、IL-6及血液流变学，而且能够实现将复杂的卒中危险因素简单化进行临床研究。
- 犀角地黄汤 /
- H型高血压 /
- TNF-α /
- IL-6 /
- 血液流变学
Abstract: OBJECTIVE To investigate the effects of Xijiao Dihuang Decoction on the TNF-α， IL-6 and hemorheology of stagnated-heat syndromes (elevated homocysteine levels-Hcy accompanied with hypertension ) and H-hypertensive rats.METHODS Modeling stagnated-heat syndromes and H-hypertensive rats， then they were treated with three different doses Xijiao Dihuang Decoction respectively (0.75 g crude drug/mL，1.5 g crude drug/mL， 3.0 g crude drug/mL) as well as a control group with no treatment. To detect and analyze the TNF-α， IL-6， and hemorheology statistically.RESULTS The TNF-α， IL-6 and hemorheology in the treatment group were significantly different compared with the control group. The difference was statistically significant (P<0.01)， with low and middle dose more effective.CONCLUSION Xijiao Dihuang Decoction can effectively intervene the TNF-α， IL-6， and hemorheology of stagnated-heat syndromes and H-hypertensive rats， thus achieving the simplification of complex risk factors for stroke in clinical studies.
- Xijiao Dihuang Decoction /
- H-hypertension /
- TNF-α /
- IL-6 /
- hemodynamics

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参考文献(6)

[1]	胡大一，徐希平．有效控制“H型”高血压——预防卒中的新思路[J]．中华内科杂志，2008， 47（12）：976-977．
[2]	Hu DY， Xu XP. Effective control the H-hypertension:a new method to prevent stroke[J]. Chin J Intern Med， 2008， 47(12): 976-977.
[3]	Rost NS， Wolf PA， Kase CS， et al. Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study[J]. Stroke， 2001， 32(11): 2575-2579.
[4]	Vucevi D， Radak D， Radosavljevi T， et al. Inflammatory process in atherogenesis: new facts about old flame[J]. Med Pregl， 2012， 65(9/10): 388-395.
[5]	Wong BW， Meredith A， Lin D， et al. The biological role of inflammation in atherosclerosis[J]. Can J Cardiol， 2012， 28: 631-641.
[6]	Tuttolomondo A， Di Sciacca R， Di Raimondo D， et al. Inflammation as a therapeutic target in acute ischemic stroke treatment[J]. Curr Top Med Chem， 2009， 9(14): 1240-1260.