降脂丸预防大鼠动脉粥样硬化的研究
Study on Preventing Rat Atherosclerosis with Jiangzhi Pills
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摘要: 目的 观察预防性给药降脂丸对动脉粥样硬化大鼠(atherosclerosis,AS)血脂及主动脉弓形态学变化的影响。方法 将72只SD大鼠随机分为①降脂丸高剂量组、②降脂丸中剂量组、③降脂丸低剂量组、④绞股蓝干预组、⑤空白组、⑥模型组。空白组正常饮食,模型组灌胃脂肪乳剂,其余各组在造模的同时给予相应药物治疗。分别在第15天、第25天、第34天后测定甘油三酯(TC)、低密度脂蛋白(LDL-C)及C反应蛋白(CRP),最后观察主动脉弓及肝脏病理学形态。结果 降脂丸高、中、低剂量组在给药后15天、25天、34天的TC、LDL-C含量显著低于模型组(P<0.01),且效果优于绞股蓝;降脂丸高、中、低剂量组的CRP显著低于模型组(P<0.01),高剂量组的效果优于绞股蓝,中、低剂量组作用与绞股蓝类似;灌胃脂肪乳剂的大鼠体质量明显较轻,降脂丸高、中剂量组肝指数与模型组比有显著差异(P<0.01);肝脂肪化程度⑥>④>③=②>①>⑤;主动脉弓硬化情况⑥>②=③>④>①>⑤。结论 降脂丸具有一定的降血脂作用,可以有效的预防AS及脂肪肝的发生。Abstract: OBJECTIVE To observe the effect of prophylactic medication Jiangzhi Pill on blood fat of atherosclerosis rats (atherosclerosis, AS) and morphological changes of arcus aortae. METHODS 72 SD rats were randomly divided into six groups: (1)Jiangzhi Pill high dose group, (2)Jiangzhi Pill middle dose group, (3)Jiangzhi Pill low dose group, (4)gynostemma pentaphylla intervention group, (5)blank group and (6)model group. The normal diet was given to the blank group and the model group was given lipid emulsion gavage. The other groups were given corresponding drug treatment while modeling. Measure the triglycerides (TC), low density lipoprotein (LDL-C) and C-reactive protein (CRP) respectively on D15, 25, 34. Lastly, the arcus aortae and liver pathology morphology was observed.RESULTS The TC, LDL-C in Jiangzhi Pill of the high, middle and low dose groups after drug administration of 15 days, 25days, 34days were significantly lower than the model group (P<0.01), better than gynostemma pentaphylla. CRP in Jiangzhi Pill of the high, middle and low dose groups was significantly lower than those of the model group (P<0.01) and the effect of high dose group was better than gynostemma pentaphylla and the middle and low dose groups were similar to gynostemma pentaphylla. The rat weight given lipid emulsion gavage was significantly lighter. Liver index in Jiangzhi Pill of the high, middle dose groups, compared with model group, were significantly different (P<0.01). Liver fat degree: (6)>(4)>(3)=(2)>(1)>(5). The hardening situation of arcus aortae: (6)>(2)=(3)>(4)>(1)>(5).CONCLUSION Jiangzhi Pill have a antihyperlipidemic effect and can effectively prevent the occurrence of AS and fatty liver.
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Key words:
- lipid-lowering pill /
- atherosclerosis /
- blood fat /
- prevention
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