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中药罗勒胶囊对大鼠移植性肝癌TACE后VEGF和Bcl-2表达的影响

冯兵 朱莹 贺嵩敏 朱亚珍 郑广娟

冯兵, 朱莹, 贺嵩敏, 朱亚珍, 郑广娟. 中药罗勒胶囊对大鼠移植性肝癌TACE后VEGF和Bcl-2表达的影响[J]. 南京中医药大学学报, 2013, 29(2): 146-150.
引用本文: 冯兵, 朱莹, 贺嵩敏, 朱亚珍, 郑广娟. 中药罗勒胶囊对大鼠移植性肝癌TACE后VEGF和Bcl-2表达的影响[J]. 南京中医药大学学报, 2013, 29(2): 146-150.
FENGBing, ZHUYing, HESong-min, ZHUYa-zhen, ZHENGGuang-juan. Effects of Basil Capsules on Expressions of VEGF and Bcl-2 for Transplanted Liver Cancer in rats after TACE[J]. Journal of Nanjing University of traditional Chinese Medicine, 2013, 29(2): 146-150.
Citation: FENGBing, ZHUYing, HESong-min, ZHUYa-zhen, ZHENGGuang-juan. Effects of Basil Capsules on Expressions of VEGF and Bcl-2 for Transplanted Liver Cancer in rats after TACE[J]. Journal of Nanjing University of traditional Chinese Medicine, 2013, 29(2): 146-150.

中药罗勒胶囊对大鼠移植性肝癌TACE后VEGF和Bcl-2表达的影响

Effects of Basil Capsules on Expressions of VEGF and Bcl-2 for Transplanted Liver Cancer in rats after TACE

  • 摘要: 目的 观察罗勒胶囊对大鼠移植性肝癌经肝动脉化疗栓塞术(TACE)后细胞中VEGF和Bcl-2表达的影响,探讨罗勒胶囊对肝肿瘤TACE后乏氧微环境的影响及意义。方法 建立大鼠移植性肝癌模型,10 d后将造模成功的大鼠随机分为5组。对TACE+生理盐水组和TACE+罗勒胶囊高、中、低剂量组4组大鼠进行TACE,并分别给予生理盐水10 mL/(kg·d)和罗勒胶囊300、150、75 mL/(kg·d) ig,对非TACE对照组大鼠只进行开腹操作,不进行TACE。给药10 d后取出移植性肝癌病理标本,免疫组化法检测肿瘤组织中VEGF和Bcl-2表达情况。结果 瘤质量:行TACE的4组大鼠与非TACE组比较均明显减轻(P<0.05,P<0.01),TACE+罗勒胶囊高剂量组较TACE+生理盐水组显著减轻(P<0.05);VEGF和Bcl-2阳性表达率:TACE+生理盐水组与非TACE组比均显著升高(P<0.01);TACE+罗勒胶囊高、中、低剂量组较TACE+生理盐水组显著降低(P<0.01);TACE+罗勒胶囊高剂量组较TACE+罗勒胶囊中、低剂量组显著降低(P<0.05,P<0.01)。结论 中药罗勒胶囊能改善肝肿瘤局部的乏氧微环境并促进细胞凋亡,使肿瘤组织中VEGF和Bcl-2表达降低,抑制大鼠移植性肝癌TACE术后肿瘤的侵袭和转移。

     

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出版历程
  • 收稿日期:  2013-01-11
  • 修回日期:  2013-02-22
  • 刊出日期:  2013-03-10

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