通塞脉片治疗气阴两虚型膝关节骨性关节炎50例
Treatment of Tongsaimai Tablet in 50 Cases Knee Osteoarthritis of Qi-Yin Deficiency
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摘要: 目的 观察通塞脉片治疗气阴两虚型膝骨关节炎的疗效和安全性。方法 将100例气阴两虚型膝骨关节炎患者按随机数字表法随机分成通塞脉片治疗组50例和盐酸氨基葡萄糖对照组50例,分别于治疗前及疗程结束后测定和记录患者疼痛、步行能力;疼痛、上下楼梯能力;屈曲角度及强直、高度挛缩;肿胀及总疗效改善各项指标评分,进行血尿便常规、肝肾功能检查,记录服药期间的不良反应。结果 2组治疗前后测患者的疼痛、步行能力;疼痛、上下楼梯能力;屈曲角度及强直、高度挛缩;肿胀及总疗效改善各项指标评分差异有统计学意义(P<0.05),治疗组较对照组指数改善更为明显(P<0.05);血、尿、便常规、肝肾功能检查治疗前后均未见异常。结论 通塞脉片具有缓解和改善膝关节疼痛、僵硬、功能障碍、肿胀的作用,是治疗膝骨关节炎安全且行之有效的药物。Abstract: OBJECTIVE To observe the therapeutic effect and safety of Tongsaimai Tablet in treating knee osteoarthritis (OA) of qi-yin deficiency type. METHODS 100 patients with knee osteoarthritis of qi-yin deficiency type were divided into treatment group equally assigned,according to randomizing number table,to the treatment group (50 cases) treated with Tongsaimai Tablet and the control group (50 cases) treated with glucosamine hydrochloride by random number table method. The indexes, which reflecting the degree of joint pain and walk capacity,pain and difficulty in up and down stairs, buckling angle and degree of stiffness, contracture, and swell, the improvement of patients symptoms and the integral estimation in patients, were measured and recorded before and after treatment. Moreover, blood, urinary and feces routine tests,liver and kidney function examination,and the adverse reaction that occurred in the treatment period were observed. RESULTS Indexes mentioned above in both groups before and after treatment showed significant statistical differences (P<0.05). Indexes in treatment group was more significant than that of the control group. No abnormal result was found, urinary and feces routine tests,liver and kidney function examination. CONCLUSION Tongsaimai Tablet is a safe and effective drug for the treatment of knee osteoarthritis,which could alleviate the joint pain,stiffness,dysfunction and swell.
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