痛痹颗粒冲剂对膝骨性关节炎WOMAC指数的影响

基金项目: 江苏省中医药局科研基金资助项目(Z030)

摘要: 目的自拟痛痹颗粒冲剂,系统观察中医药治疗膝骨性关节炎(osteoarthritis,以下简称膝OA)的临床疗效。方法选用膝OA的早中期患者50例,治疗组30例,对照组20例,治疗组痛痹颗粒冲剂每日1剂,分2次口服,对照组选用硫酸氨基葡糖(维骨力)每次0.25 g,每日3次,观察指标采用了100 mm目测模拟疼痛标尺线(VAS)、WOMAC骨关节炎指数、肿胀、压痛积分、起效时间、合并用药及临床疗效。结果2组治疗前后疼痛、WOMAC骨性关节炎指数、肿胀、压痛指数均有显著性意义(P<0.05,P<0.01)。其中VAS、WOMAC骨关节炎指数组间有显著性意义(P<0.05)。治疗组起效时间较对照组快,组间有显著性意义(P<0.05),治疗组疗效优于对照组,P<0.01。结论痛痹颗粒冲剂治疗膝骨性关节炎能明显改善临床症状,综合疗效优于对照组。
- WOMAC骨关节炎指数 /
- 膝骨 /
- 痛痹颗粒冲剂

[1]	Kelley WN,Ruddy S,Harris ED,et al.Textbook of Rheumatology.15th ed[M].Philadelphia:Saunders,1997.1369-1382.
[2]	Reginster YJ,Deroisy R,Paul I,et al.Glucosamine Sulfatesignificantly reduces progression of knee OA over 3years:a large randomised,Placebocontrolled,double-blind prospective trial[J].Arthritis Rheum,1999,42 (suppl):721.
[3]	Altman RD.Criteria for classification of clinical osteoarthritis[J].J Rheumatol,1991,18 (suppl27):10-12.
[4]	Kellamy JH,Lawrence JS.adiological assessment of osteoarthrosis[J].Ann Rheum Dis,1957,16:494-502.
[5]	Bellamy N,Buchanan WW,Goldsmith CH,et al.Validation study of WOMAC:A healthy status instrument for measuring clinically-important patient-relevant outcomes following total hip or knee arthroplasty in osteoarthritis[J].J Orthop Rheumatol,1988,1:95-98.
[6]	陈佑邦.中医内科病症诊断疗效标准[S].南京:南京大学出版社,1994.30.
[7]	周秋丽,王丽娟,郭颖杰,等.鹿茸多肽对实验性骨折的治疗作用及机制研究[J].白求恩医科大学学报,1999,25(5):586-588.
[8]	樊粤光,谢国平.补肝肾方血清对体外培养大鼠软骨细胞的影响[J].中药新药与临床药理,2004,15(4):257-258.