口服吸收模型在中药研究中的应用进展

单进军 狄留庆 吴皓

口服吸收模型在中药研究中的应用进展

单进军狄留庆吴皓

南京中医药大学中医药研究院, 江苏南京210046

基金项目: 江苏省自然科学基金（BK2005150）

计量
- 文章访问数: 967
- HTML全文浏览量: 11
- PDF下载量: 0
- 被引次数: 0
出版历程
- 收稿日期: 2007-02-28
- 刊出日期: 2007-07-10

Advancement in Application of Oral Absorption Models in Research of Chinese Drugs

SHAN Jin-jun, DI Liu-qing, WU Hao

Institute of Chinese Medicine and Pharmacology of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210046, China

摘要

摘要: 以国内外近期文献为依据，介绍了各种口服吸收模型的实验方法和特点，并对近几年来口服吸收模型在中药研究中的应用进行了总结。提示开展中药口服吸收的研究不但可以为中药口服剂型方案和质量标准研究提供科学依据，而且可以结合中医药理论，科学地阐述中药复方的配伍规律，从而为中医药现代化提供有益的探索.

Abstract: This paper deals with the experimental methods and features with oral absorption models and the application of these methods in recent years. The authors believe that the research in oral absorption of Chinese drugs can not only provide scientific bases for plans of the Chinese drug oral preparation forms and quality control, but also scientifically enunciate the regularities in drug combination in compound prescriptions, thus providing useful exploration for the modemization of Chinese medicine and pharmacology.

HTML全文

参考文献(17)

[1]	Han van de W,Eric G.ADMET in silico modeling:towards prediction paradise?[J].Nat Rev Drug Discov,2003,2:192.
[2]	杨修伟,杨晓达,蒲小平,等.创新药物研究中的吸收、分布、代谢、排泄/毒性(ADME/T)平台建设[J].北京大学学报(医学版),2004,36(1):5.
[3]	Anand BS,Patel J,Mitra AK.Interaction of the dipeptide easter prodrugs of acyclovir with the intestinal oligopeptide transporter:Competitive inhibition of glycylsarcosine transportin human intestinal cell line-Caco-2[J].J Pharmacol Eep Ther,2003,304(2):781.
[4]	刘昌孝.中药药代动力学研究的难点和热点[J].药学学报,2005,40(5):395.
[5]	Andlauer W,Kolb J,Siebert K,et al.Assessment of resveratrol bioavailability in the perfused small intestine of the rat[J].Drugs Ex P Clin Res,2000,26:47.
[6]	Cheng C,Abhijit R,Peter A.In silico strategies for modeling membrane transporter function[J].Drug Discov Today,2005,10(9):663.
[7]	Stewart BH,Chan OH,Lu RI,et al.Comparison of intestinal permeabilities determined in multiple in vitro and in situ models:relationship to absorption in humans[J].Pharm Res,1995,12:693.
[8]	Barthe L,Woodley J,Houin G.Gastrointestinal absorption of drugs:methods and studies[J].Fundam Clin Pharmacol,1999,13:154.
[9]	宋洪涛,谢彤康,鲁平,等.川芎嗪大鼠在体肠吸收动力学[J].中国医院药学杂志,2005,25(10):905.
[10]	宋洪涛,郭涛,张跃新,等.阿魏酸在大鼠体内肠吸收动力学的研究[J].中草药,2005,36(10):1514.
[11]	杨星钢,张立波,潘卫三,等.芍药苷大鼠在体肠吸收动力学的研究[J].中国药学杂志,2006,41(11):854.
[12]	Takayuki A,Kazuhisa I,Takashi M,et al.Permeability of the flavonoids liquiritigenin and its glycosides in licorice roots and davidigenin,a hydrogenated metabolite of liquiritigenin,using human inteatinal cell line Caco-2[J].J Ethnopharmacol,2003,89:285.
[13]	韩曼,韩丽妹,王青松,等.三七皂苷的口服吸收机制[J].药学学报,2006,41(6):498.
[14]	廖正根,平其能,萧伟,等.桂枝茯苓胶囊中有效成分的大鼠在体肠吸收研究[J].中国天然药物,2005,3(5):303.
[15]	《国家药典》委员会.中华人民共和国药典.2005年版[S].北京:化学工业出版社,2005.117.
[16]	李芸霞,蒋学华,周静.大鼠在体吸收连翘苷的机理研究[J].华西药学杂志,2005,20(5):387.
[17]	Leena L,Heli K,Ann MK,et al.N-in-One Permeability Studies of Heterogeneous Sets of Compounds Across Caco-2 Cell Monolayers[J].Pharm Res,2003,20(1):187.