大剂量血脂康在经皮冠状动脉介入治疗中的心肌保护作用

刘尊齐 崔连群 曾庆师 王勇 孔庆赞 郭拥军 刘继东 李峰 盖玉生 唐元升

大剂量血脂康在经皮冠状动脉介入治疗中的心肌保护作用

刘尊齐崔连群曾庆师王勇孔庆赞郭拥军刘继东李峰盖玉生唐元升

山东大学山东省立医院山东济南250000(刘尊齐, 崔连群, 王勇, 孔庆赞, 郭拥军, 刘继东, 李峰, 盖玉生, 唐元升), 山东大学齐鲁医院山东济南250000(曾庆师)

基金项目: 山东省自然科学基金(Y2005C17)，山东省医药卫生科技发展计划(2005HW090)

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出版历程
- 收稿日期: 2005-10-11
- 修回日期: 2005-12-10
- 刊出日期: 2006-03-10

The Myocardial Protective Effects of High-dose Atorvastatin during Percutaneous Coronary Intervention in Patients with Unstable Angina

摘要

摘要: 目的研究不稳定型心绞痛(unstable aninia,UA)患者在经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗前应用大剂量血脂康的心肌保护作用。方法对196例临床确诊为UA的患者按随机原则分别入选A组和B组,在相似常规治疗的基础上分别接受1.2 g/d和2.4 g/d血脂康治疗,另设同期住院服用阿托伐他汀20 mg/d的UA患者作为对照。随后对所有病人进行冠状动脉造影和PCI治疗。测定PCI术前及术后48 h的血清CK-MB、cTnI和cTnT的浓度,并随访0.5年内的冠脉事件和左室射血分数。结果PCI术前3组患者临床及血清CK-MB、cTnI和cTnT阳性率无明显差别;术后48 h 3组CK-MB阳性率也无明显差别,但血清cTnI和cTnT阳性率B组明显低于A组和C组(P<0.05);术后0.5年主要冠脉事件B组明显少于A组和C组(P<0.05);左室射血分数B组明显高于A组和C组(P<0.05)。A、C 2组的监测指标无明显区别。结论PCI术前大剂量血脂康治疗对心肌具有保护作用,其减少心肌损伤可能是PCI术后冠脉事件减少和左室射血分数增加的关键因素。
- 血脂康 /
- 经皮冠状动脉介入治疗 /
- 不稳定型心绞痛 /
- 心肌保护

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参考文献(8)

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