内异方对子宫内膜异位症生殖内分泌调节的实验研究

王瑞霞, 俞超芹, 俞瑾, 宋艳华, 石书芳

内异方对子宫内膜异位症生殖内分泌调节的实验研究

王瑞霞, 俞超芹, 俞瑾, 宋艳华, 石书芳

第二军医大学长海医院中医科, 第二军医大学长海医院中医科, 复旦大学附属妇产科医院, 第二军医大学长海医院中医科, 第二军医大学长海医院中医科上海 200433, 上海 200433, 上海 200011, 上海 200433, 上海 200433

基金项目: 国家自然科学基金(30070942)

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出版历程
- 修回日期: 2005-03-03
- 刊出日期: 2005-07-10

Experimental Study on Regulating Effect of Neiyi Recipe on Reproductive Endocrinology in Endometriosis

WANG Rui-xia, YU Chao-qin, YU Jin, SONG Yan-hua, SHI Shu-fang

摘要

摘要: 目的研究内异方对子宫内膜异位症(内异症)生殖内分泌的调节作用。方法建立内异症大鼠模型和假手术模型,放射免疫法检测血雌二醇(E2)、下丘脑促性腺素释放激素(GnRH),垂体黄体生成激素(LH)、泌乳素(PRL)和外周血E2的水平。结果内异方治疗组异位灶重量显著低于非治疗组(P<0.05),非治疗组下丘脑GnRH的含量显著低于假手术组和内异方治疗组(P<0.05),内异方治疗组外周血E2、垂体PRL的含量显著低于非治疗组(P<0.05)。结论内异方可通过下丘脑-垂体-卵巢轴,起到调节内异症生殖内分泌的作用。
- 子宫内膜异位症 /
- 生殖内分泌 /
- 中药 /
- 内异方
Abstract: OBJECTIVE To investigate into the regulating effect of Neiyi Recipe on reproductive endocrinology in endometriosis. METHOD Endometriosis rat models and pseudo - surgery models were established and radioimmunoassay was used to examine the levels of blood E2, hypothalamus GnRH, pituitary body LH and PRL and peripheral blood E2. RESULT The ectopic focus weight in the treatment group was markedly lower than the non - treatment group ( P < 0.05 ) . The hypothalamus GnRH content in the non - treatment group was markedly lower than the pseudo- surgery group and the treatment group ( P < 0.05) . The contents of peripheral blood E2 and Pituitary body PRL were markedly lower than the non - treatment group ( P < 0.05) . CONCLUSION Neiyi Recipe can regulate reproductive endocrinology through hypothalamus - pituitary gland - ovary axis.
- endometriosis /
- reproductive endocrinology /
- Chinese drugs /
- Neiyi Recipe

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参考文献(10)

[1]	俞超芹,刘玉环,彭新萍,等.子宫内膜异位症白细胞介素-8与白细胞介素-10水平及内异方对其调节作用[J].中国中西医结合杂志,2000,20(8):603.
[2]	石一复.子宫内膜异位症[M].上海.上海科学技术出版社,2002.14.
[3]	贺又娥,张以文,韩美玲,等.子宫内膜异位症患者泌乳素分泌功能及其与黄体功能不足和不育的关系[J].中华妇产科杂志,1993,28(1):14.
[4]	顾一村,高永利,张令浩.隐匿性高催乳素血症与不孕[J].国外医学·妇产科分册,2002,29(2):85.
[5]	于永兰,郭新华,叶元华.不孕症妇女血清催乳素水平分析[J].同济医科大学学报,1995,24(1):64.
[6]	Cunha- Filho JS, Gross JL, Lemos NA, et al. Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis[J]. Horm Metab Res, 2001,33(4):216.
[7]	Gurates B, Bulun SE. Endometriosis: The ultimate hormonal disease[ J ]. Seminars in Reproductive Medicine, 2003,21 (2):125.
[8]	Provinciali M, Di Stefano G, Muzzioli M, et al. Relationship between 17 - beta- estradiol and prolactin in the regulation of natural killer cell activity during progression of endometriosis[ J].J Endocrinol Invest, 1995,18(8): 645.
[9]	俞超芹,蔡在龙,刘玉环,等.内异方对子宫内膜异位症大鼠细胞因子含量、血管内皮细胞生长因子mRNA表达的影响[J].安徽中医学院学报,2002,21(6):36.
[10]	Cottreau CM, Ness RB, Modugno F, et al. Endometriosis and its treatment with danazol or lupron in relation to ovarian cancer[J]. Clin Cancer Res,2003,9(14): 5142.