橘荔散结丸对子宫肌瘤雌、孕激素受体水平的影响
Effect of Lizhi Sanjie Pill on Levels of Estrogen and Progestin of Hysteromyoma Patients
-
摘要: 目的观察橘荔散结丸对子宫肌瘤患者子宫肌层及瘤体组织雌激素受体(ER)和孕激素受体(PR)的影响。方法选用免疫组化的方法,检测15例仅服用橘荔散结丸3个月以上又手术治疗的患者子宫肌瘤及子宫肌层ER、PR水平,选择15例未曾服用相关中西药物而手术治疗的子宫肌瘤患者做对照。结果2组肌瘤组织EP、PR的水平均高于子宫肌层组织(P<0.05),而对照组EP、PR显著高于治疗组(P<0.05)。结论降低子宫肌瘤患者子宫肌层及其瘤体组织中的EP、PR水平可能是橘荔散结丸治疗子宫肌瘤的主要机理之一。Abstract: OBJECTIVE To observe the effect of Lizhi Sanjie Pill on the levels of estrogen (ER) and progestin (PR) of hys teromyoma patients. METHOD Immunohistochemical method was used to detect ER and PR levels of hysteromyoma and myometrium of 15 patients who had taken exclusively Lizhi Sanjie Pill for three months and had received surgery, compared with another 15 patients who had not taken the pill but also had received surgery. RESULT The ER and PR levels of hysteromyoma were higher than those of myometrium ( P < 0.05) and the ER and PR levels in the control group were markedly higher than those in the treatment group (P< 0. 05). CONCLUSION The reduction of the ER and PR levels is probably one of the main mechanisms of Lizhi Sanjie Pill in the treatment of hysteromyoma.
-
Key words:
- Lizhi Sanjie Pill /
- hysteromyoma /
- estrogen receptor /
- progestin receptor
-
[1] 陈贵安,张丽珠.子宫肌瘤与组织胞浆内雌、孕激素受体含量及血内雌二醇、孕酮水平关系的探讨[J].中华妇产科杂志,1984,19(2):88. [2] 吴际,云英.子宫肌瘤组织雌、孕激素受体及细胞增殖相关抗原与激素及细胞核体关系的探讨[J].中华妇产科杂志,1995,30(10):603. [3] 罗清华,冯金英,陈碧云.橘荔散结丸治疗子宫肌瘤150例临床体会[J].新中医,1990,22(8):26. [4] 陈小峰,王培训,李道中,等.橘荔散结丸治疗子宫肌瘤的NK细胞活性观察[J].中成药,1988,10(11):21. [5] 邵丽黎,贾彩凤.女病诊疗全书·中国中西医专科专病临床大系[M].北京:中国中医药出版社,2000.672. [6] 张奇文,朱锦善,朱金凤.妇科杂病(妇科医籍辑要丛书)[M].北京:人民卫生出版社,1995.98. [7] 赵卫红,朱荫芝.雌、孕激素受体对子宫肌瘤生长的影响[J].北京医学,2002,24(6):304. [8] 李克敏,毕慧,郑淑蓉,等.小剂量米非司酮对子宫肌瘤雌、孕激素受体的影响[J].北京医科大学学报,1998,30(1):67. [9] 纪巍,辛晓燕,陈必良.胰岛素样生长因子1及其受体对子宫肌瘤生长的影响[J].中国肿瘤临床与康复,2003,10(1):24. -
点击查看大图
计量
- 文章访问数: 1158
- HTML全文浏览量: 3
- PDF下载量: 0
- 被引次数: 0
下载:
