不同类型心绞痛患者血清中高敏C反应蛋白的含量及药物干预
Content of Hypersensitivity C Reactive Protein in Serum of Patients with Different Kinds of Angina Pectoris and Drug Interven- tion
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摘要: 目的观察稳定型和不稳定型心绞痛患者血清中的高敏C反应蛋白的含量及药物干预影响。方法应用酶联免疫吸附法(ELISA)检测60例稳定和不稳定型心绞痛患者的高敏C反应蛋白(hsCRP),并将不稳定型心绞痛分为治疗组17例和对照组17例,对照组予西药常规治疗,中药组加服通心络胶囊,观察2组治疗8周后其水平含量的变化。结果不稳定型心绞痛患者血清hsCRP含量明显高于稳定型心绞痛(P<0.01),治疗组血清hsCRP与自身治疗前比较明显改善(P<0.01),治疗前后差值与对照组比较有极显著性差异(P<0.01)。结论hsCRP的升高是反映不稳定型心绞痛病情变化的敏感指标,通心络胶囊能够通过改善hsCRP的水平而延缓心绞痛发作。Abstract: OBJECTIVE To observe the content of hypersensitivity C reactive protein (hsCRP) in the serum of patients with stable and unstable angina pectoris and the effect of drug intervention. METHOD ELISA method was used to detect hsCRP level of 60 patients with stable and unstable angina pectoris, and those with unstable angina pectoris were divided into a treatment group of 17 patients treated with the Chinese medicine Tongxinluo Capsule as well as western medicine, and a control group of another 17 patients treated only with western medicine. The patients were treated for 8 weeks. RESULT The hsCRP level of those with unstable angina pectoris was markedly higher than those with stable angina pectoris( P < 0.01). In the treatment group, hsCRP level was improved markedly as compared with the level before the treatment( P < 0.01), with significant difference from the control group after the treatment ( P < 0.01) . CONCLUSION The rise of hsCRP level is an indicator for the change of the disease conditions of those with unstable angina pectoris, and Tongxinluo Capsule can relieve the attack of angina pectoris by improving CRP level.
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Key words:
- angina pectoris /
- high sensitivity C reactive protein /
- Tongxinluo Capsule
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