动物药水牛角基础与应用研究进展

汤佳瑶; 武文星; 朱悦; 郭盛; 赵明; 曹鹏; 刘睿; 段金廒

doi:10.14148/j.issn.1672-0482.2022.0880

动物药水牛角基础与应用研究进展

doi: 10.14148/j.issn.1672-0482.2022.0880

汤佳瑶^1,,
武文星¹,
朱悦¹,
郭盛¹,
赵明^{1, 2},
曹鹏^{1, 2},
刘睿^{1, 2, ,},
段金廒^{1, 2, ,}

1.
南京中医药大学/江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心/国家中医药管理局中药资源循环利用重点研究室, 江苏南京 210023
2.
动物类中药与功能肽国际合作联合实验室, 江苏南京 210023

基金项目:

国家自然科学基金面上项目 81973450

国家重点研发计划 2018YFC1706100

江苏省高校“青蓝工程”中青年学术带头人

江苏省农业科技自主创新项目 CX(22)3173

南京中医药大学中药学一流学科开放课题 2020YLXK009

详细信息

作者简介:
汤佳瑶, 女, 硕士研究生, E-mail: jiayao_127@163.com

刘睿, 教授, 硕士研究生导师, University of Wisconsin-Madison访问学者。主要从事动物药资源化学及海洋药用生物资源开发利用研究。先后主持国家自然科学基金等省部级以上科研项目7项入选江苏省“青蓝工程”中青年学术带头人、江苏省“333工程”第三层次人才、中华中医药学会“青年人才托举工程”以第一作者或通讯作者在Analytical Chemistry、Food Chemistry、Analytica Chimica Acta等期刊发表学术论文60余篇, 获国家授权发明专利20余项, 获江苏省科学技术二等奖, 国家海洋科学技术二等奖

通讯作者:
刘睿, 男，教授, 主要从事动物药资源化学研究及海洋药用生物资源开发利用研究, E-mail: liurui@njucm.edu.cn

段金廒, 男，教授, 博士生导师, 主要从事中药资源化学研究及资源循环利用研究, E-mail: dja@njucm.edu.cn

中图分类号: R282.74
计量
- 文章访问数: 73
- HTML全文浏览量: 12
- PDF下载量: 20
- 被引次数: 0
出版历程
- 收稿日期: 2022-08-15
- 网络出版日期: 2022-10-25
- 发布日期: 2022-10-10

Research Progress on the Basis and Application of Buffalo Horn

TANG Jia-yao^1
,,
WU Wen-xing¹,
ZHU Yue¹,
GUO Sheng¹,
ZHAO Ming^{1, 2},
CAO Peng^{1, 2},
LIU Rui^{1, 2
, ,},
DUAN Jin-ao^{1, 2
, ,}

1.
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, National Administration of Traditional Chinese Medicine Key Laboratory for Chinese Medicine Resources Recycling Utilization, Nanjing University of Chinese Medicine, Nanjing 210023, China
2.
Animal-Derived Chinese Medicine and Functional Peptides International Collaboration Joint Laboratory, Nanjing 210023, China

摘要

摘要: 水牛角为牛科动物水牛Bubalus bubalis Linnaeus的角, 具有清热凉血, 解毒, 定惊的功效, 主要用治温病高热, 神昏谵语, 发斑发疹, 吐血衄血, 惊风, 癫狂等疾病。查阅历代本草书籍和文献资料, 系统整理水牛角的基原、性味功效、配伍应用、物质组成、鉴定与质量评价方法、生物效应评价、现代临床应用以及作为犀角代用资源的应用历史, 为进一步阐明水牛角的功效物质基础、作用机制及质量标准提升等提供研究思路与策略。通过梳理与凝练, 以期为水牛角基础与应用研究提供依据与借鉴, 为完善水牛角质量与药效评价体系、推动中药资源产业的可持续发展提供科学的理论依据。
- 水牛角 /
- 功效物质 /
- 生物效应 /
- 质量控制 /
- 产业发展
Abstract: Buffalo horn is the horn of Bubalus bubalis Linnaeus. It has the effect of clearing heat and cooling blood, resolve toxin and stabilize fright. It is mainly used to treat febrile diseases, high fever, clouded spirit and dilirious speech, macular eruption and exanthema, blood ejection and spontaneous external bleeding, fright wind, mania and withdrawal, etc. In this paper, we consulted the herbal books and documents of the past dynasties, and systematically sorted out the basis of buffalo horn, its properties, taste, compatibility and application, material composition, identification and quality evaluation methods, biological effect evaluation, modern clinical application and application history as a substitute resource for rhino horn. To provide research ideas and strategies for further clarifying the efficacy and material basis of buffalo horn, the mechanism of action and the improvement of quality standards. Through the combing and condensing of this paper, it provides a basis and reference for the basic and applied research of buffalo horn, and provides a scientific theoretical basis for improving the quality and efficacy evaluation system of buffalo horn and promoting the sustainable development of traditional Chinese medicine resources industry.
- buffalo horn /
- functional substances /
- biological effects /
- quality control /
- industrial development

HTML全文

图 1 水牛角性状外观

Figure 1. Buffalo horn trait appearance

下载: 全尺寸图片幻灯片

图 2 犀角药用历史及水牛角代用现状

Figure 2. The history of rhinoceros horn replacement by buffalo horn

下载: 全尺寸图片幻灯片

表 1 历代本草著作对水牛角的性味功效记载

Table 1. Medicinal properties of Bubalus bubalis L. from Chinese materia medica books

书名	年代及作者	性味归经	功效主治
《名医别录》	南北朝陶弘景	-	治时气寒热头痛
《新修本草》	唐苏敬	-	疗时气寒热头痛
《日华子本草》	五代十国日华子	-	治热毒风并壮热
《证类本草》	北宋唐慎微	-	疗时气寒热头痛
《太平圣惠方》	宋王怀隐	-	牛角烧灰, 酒服方寸匕, 日五服可治石淋, 破血
《圣济总录》	宋赵佶	-	牛角、羊角(烧灰)等分, 猪脂调涂可治赤秃发落
《本草纲目》	明李时珍	苦, 寒, 无毒	治淋, 破血
《陆川本草》	清赵学敏	辛、咸, 寒	凉血解毒, 止衄; 治热病昏迷, 麻痘斑疹, 吐血, 衄血, 血热, 溺赤
《晶珠本草》	清帝玛尔·丹增彭措	-	清热, 利水, 治下落水肿
《四川中药志》	1960年中国科学院四川分院中医中药研究所	-	治风热头痛, 喉头红肿, 小儿惊风及吐血
《中草药学》	1973年浙江省西医学习中医试用教材编写组	-	治上感等热病症, 流行性乙型脑炎, 原发性血小板减少性紫癜, 肝炎, 精神分裂症。
《全国中草药汇编》	1975年《全国中草药汇编》编写组	-	热病惊厥, 高热, 神昏, 谵语, 吐血, 衄血, 斑疹, 血小板减少性紫癜, 精神分裂症, 小儿夏季热。
《中药大辞典》	2006年南京中医药大学	-	清热、凉血、解毒。治热病头痛, 壮热神昏, 斑疹, 吐衄, 小儿惊风, 喉痹咽肿
《中华人民共和国药典》	2020年国家药典委员会	苦, 寒, 归心、肝经	清热解毒, 凉血, 定惊。用于温病高热, 神昏谵语, 发斑发疹, 吐血衄血, 惊风, 癫狂

下载: 导出CSV

表 2 水牛角方药主治病证分布

Table 2. Distribution of main diseases and syndromes of Buffalo Horn prescription

序号	主治病症	方数
1	温热病	17
2	神烦谵语	6
3	斑疹	4
4	咽喉肿痛	3
5	口渴无津	4
6	目昏	3
7	小儿惊厥	3
8	中风、抽搐	4
9	心烦气喘	1
10	风湿寒痹	1
11	吐逆	1
12	单纯性肥胖症	1
13	产后血晕、难产闷乱、死胎不下	1
14	时疫霍乱	1
15	肠风、泄血	1

下载: 导出CSV

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